CENFORCE 150mg is an oral therapy for dealing with impotence in males. It is used for treating erectile dysfunction (ED) in males. It contains sildenafil citrate which inhibits Phosphodiesterase 5 (PDE 5) resulting in manifestation of action of cGMP which causes erection during sexual stimulation. It does not act as aphrodisiac; It requires an external stimuli to act. Sildenafil is the first medicine launched by Pfizer as a treatment of erectile dysfunction. It does not cure the main cause of ED.
MECHANISM OF ACTION
cGMP causes relaxation of vascular smooth muscles and augment blood flow to various body tissues. PDE5 (phosphodiesterase5) is an enzyme which degrades cGMP thereby inhibiting its action. It is found in the walls of penile blood vessels, erectile tissue of the penis and retina of the eye. Sildenafil enhances the activity and concentration of cGMP in tissues by blocking PDE5. Increased cGMP causes widening of blood vessels of the penis resulting in erection.
INDICATIONS AND USES
Sildenafil Citrate is primarily employed for erectile dysfunction (impotence) in men. It is also an effective medicine for pulmonary arterial hypertension.
Sildenafil Citrate may also be used for other purposes other than that mentioned here.
DOSAGE AND ADMINISTRATION
CENFORCE is intended to be taken by mouth only with a glass full of water. One pill should be taken about 30 minutes preceding intercourse. Its effect lasts for 4 hours. Discuss with your doctor before using it; follow the dosage regimen prescribed by your doctor. Do not take it more than once a day. Maintain a dosing interval of 24 hours. Use of grapefruit juice and meals rich in fats must be avoided with CENFORCE. They delay the action and enhance side effects of CENFORCE.